Kim, Min Jee Kim, Dong-Cheol Kwon, Jaeyoung Ryu, Seung Mok Kwon, Haeun Guo, Yuanqiang Hong, Seung-Beom Kim, Youn-Chul Oh, Hyuncheol Lee, Dongho 2024-01-19T17:34:10Z 2024-01-19T17:34:10Z 2021-09-05 2020-04-24 0163-3864 https://pubs.kist.re.kr/handle/201004/118713 Twelve metabolites were obtained from the culture media of Chaetomium nigricolor, including a new furan derivative, methyl succinyl Sumiki's acid (1), and two new atropisomers of the previously reported bis-naphtho-gamma-pyrones, (aS)-asperpyrone A and (aS)-fonsecinone A (2 and 3). The structures were elucidated by spectroscopic, chemical, and chiroptical techniques. Compounds 2 and 3 inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Compound 2 was found to inhibit nuclear factor-kappa B and c-Jun N-terminal kinase activation, in turn suppressing pro-inflammatory mediators and cytokines including nitric oxide, prostaglandin E-2, interleukin (IL)-1 beta, tumor necrosis factor-alpha, IL-6, and IL-12. English AMER CHEMICAL SOC NF-KAPPA-B Anti-inflammatory Metabolites from Chaetomium nigricolor Article 10.1021/acs.jnatprod.9b00560 1 JOURNAL OF NATURAL PRODUCTS, v.83, no.4, pp.881 - 887 JOURNAL OF NATURAL PRODUCTS 83 4 881 887 scie scopus 000529168400009 2-s2.0-85082326259 Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Article NF-KAPPA-B