El-Gamal, Mohammed, I Omar, Hany A. Semreen, Mohammad H. Younes, Israa A. Zaghloul, Youmna Y. Abbas, Ayat E. Moussa, Iman G. Hersi, Fatima Oh, Chang-Hyun 2024-01-19T17:34:51Z 2024-01-19T17:34:51Z 2022-01-25 2020-04 0045-2068 https://pubs.kist.re.kr/handle/201004/118753 A series of cycloalkanecarboxamide-containing sulfonate and sulfamate derivatives were prepared, and their antiproliferative activity was tested against NCI-60 cancer cell lines panel. Compound if possessing cyclohexyl and p-(tert-butyl)benzenesulfonate moieties was the most active among all the target compounds. It exerted broad-spectrum anticancer activity against all the nine cancer types involved in the NCI-60 panel. Additionally, compound 1g containing cyclohexyl and p-fluorobenzenesulfonate moieties was the most potent against HT29 colon cancer cell line (IC50 = 4.73 mu M) with selectivity index more than 4.23 towards HT29 than normal fibroblasts. It exerts its antiproliferative activity against HT29 through the induction of apoptosis (increasing caspase 3/7 activity) but not necrosis. Structure-activity relationship studies are presented in detail. English ACADEMIC PRESS INC ELSEVIER SCIENCE Antiproliferative activity of cycloalkanecarboxamide derivatives possessing sulfonate or sulfamate moiety Article 10.1016/j.bioorg.2020.103677 1 BIOORGANIC CHEMISTRY, v.97 BIOORGANIC CHEMISTRY 97 N scie scopus 000521282300007 2-s2.0-85080049860 Biochemistry & Molecular Biology Chemistry, Organic Biochemistry & Molecular Biology Chemistry Article STEROID SULFATASE Anticancer Antiproliferative Apoptosis Sulfamate Sulfonate