Jung, Huijin Chung, You Jung Wilton, Rosemarie Lee, Chang Heon Lee, Byung Il Lim, Jinyeong Lee, Hyojin Choi, Jong-Ho Kang, Hyuno Lee, Byeongdu Rozhkova, Elena A. Park, Chan Beum Lee, Joonseok 2024-01-19T18:00:33Z 2024-01-19T18:00:33Z 2021-09-05 2020-04 1616-301X https://pubs.kist.re.kr/handle/201004/118791 Abnormal accumulation of beta-amyloid (A beta) peptide aggregates in the brain is a major hallmark of Alzheimer's disease (AD). A beta aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been made to develop AD treatments that suppress A beta aggregate formation, thereby attenuating A beta-induced neurotoxicity. Here, the design of A beta nanodepletors consisting of ultralarge mesoporous silica nanostructures and anti-A beta single-chain variable fragments, with the goal of targeting and eliminating aggregative A beta monomers, is reported. The A beta nanodepletors impart a notable decline in A beta aggregate formation, resulting in significant mitigation of A beta-induced neurotoxicity in vitro. Furthermore, stereotaxic injections of A beta nanodepletors into the brain of an AD mouse model system successfully suppress A beta plaque formation in vivo up to approximate to 30%, suggesting that A beta nanodepletors can serve as a promising antiamylodoisis material. English WILEY-V C H VERLAG GMBH Silica Nanodepletors: Targeting and Clearing Alzheimer's beta-Amyloid Plaques Article 10.1002/adfm.201910475 1 ADVANCED FUNCTIONAL MATERIALS, v.30, no.15 ADVANCED FUNCTIONAL MATERIALS 30 15 N scie scopus 000513688500001 2-s2.0-85079733746 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article BLOOD-BRAIN-BARRIER PROTEIN AGGREGATION IN-VITRO DISEASE NEURODEGENERATION NANOPARTICLES MECHANISM PEPTIDES FIBRILS DECLINE beta-amyloid peptides Alzheimer&apos s disease nanodepletors scFv silica nanostructures