Park, Jun Yeon Lee, Jae Wook Lee, Chang-Ho Lee, Hae-Jeung Kang, Ki Sung 2024-01-19T18:01:58Z 2024-01-19T18:01:58Z 2021-09-05 2020-03-01 0960-894X https://pubs.kist.re.kr/handle/201004/118870 Guggulsterone is a bioactive plant sterol naturally found in migratory plants. It exists in various forms, and its active compounds include the isomers cis-guggulsterone (E-GS) and trans-guggulsterone (Z-GS). In this study, the anti-inflammatory effects of these two isomeric pregnadienedione steroids were investigated against lipopolysaccharide-induced inflammatory reaction in RAW264.7 mouse macrophages. Our results showed that both guggulsterones inhibited the production of NO in macrophages treated with lipopolysaccharide, with IC50 values ranging from 3.0 to 6.7 mu M. E-GS exerted higher efficacy than Z-GS, and its anti-inflammatory effects was mediated through inhibition of iNOS and COX-2 expression. English Pergamon Press Ltd. NF-KAPPA-B X-RECEPTOR INFLAMMATION EXTRACT CELLS ANTAGONIST APOPTOSIS PATHWAYS Synthesis and inhibitory effect of cis-guggulsterone on lipopolysaccharide-induced production of nitric oxide in macrophages Article 10.1016/j.bmcl.2020.126962 1 Bioorganic & Medicinal Chemistry Letters, v.30, no.5 Bioorganic & Medicinal Chemistry Letters 30 5 scie scopus 000510612700011 2-s2.0-85078201958 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article NF-KAPPA-B X-RECEPTOR INFLAMMATION EXTRACT CELLS ANTAGONIST APOPTOSIS PATHWAYS Guggulsterone Inflammation iNOS COX-2 RAW264.7