Lim, Sunwoo Lee, Hyomin Kim, Euijung Hur, Wooyoung 2024-01-19T18:03:08Z 2024-01-19T18:03:08Z 2021-09-04 2020-03 0253-2964 https://pubs.kist.re.kr/handle/201004/118937 We performed a biochemical screen against mTOR using in-house small molecule library. Two novel, structurally distinct hits were identified. Among them, a novel oxadiazole scaffold compound (2) suppressed the phosphorylation of both S6K1 and Akt1 in HeLa cells. Docking study suggested that 2 is ATP-competitive and shows a pi-pi interaction with Trp2239 and hydrogen bonds with Trp2239 and Thr2245. Through derivatization, a slightly more potent analogue (2a) was identified with IC50 of 9.6 mu M. Our study provides a starting point for discovery of novel potent mTOR inhibitors. English 대한화학회 Identification of a Novel Oxadiazole Inhibitor of Mammalian Target of Rapamycin Article 10.1002/bkcs.11965 1 Bulletin of the Korean Chemical Society, v.41, no.3, pp.296 - 303 Bulletin of the Korean Chemical Society 41 3 296 303 N scie scopus kci ART002568031 000509552200001 2-s2.0-85078656767 Chemistry, Multidisciplinary Chemistry Article MTOR PHOSPHORYLATION CANCER Mammalian target of rapamycin mTOR Inhibitor Screening 2 3-Dihydro-1 3 4-oxadiazole