Yoo, Junsang Kim, Junyeop Lee, Jeong Hun Kim, Hyein Jang, Sung Joo Seo, Hyo Hyun Oh, Seung Taek Hyeon, Seung Jae Ryu, Hoon Kim, Jongpil Moh, Sang Hyun 2024-01-19T18:03:13Z 2024-01-19T18:03:13Z 2021-09-05 2020-02-28 2045-2322 https://pubs.kist.re.kr/handle/201004/118941 Porphyra 334 (P334), a mycosporine-like amino acid (MAA), is a secondary metabolite found in diverse marine and terrestrial organisms and has several beneficial effects on fibroblast proliferation, wound healing, and antioxidant activity. Here, we report that P334 accelerates the cell reprogramming process of mouse tail-tip fibroblasts (TTFs) and human dermal papilla (HDP) cells into induced pluripotent stem cells (iPSCs). We found that P334 significantly improved the cell reprogramming efficiency by activating the tri-methylation of histone 3 lysine 4 (H3K4me3), which controls mesenchymal to epithelial transition (MET) during the reprogramming process. Thus, we found that P334 directly regulates epigenetic changes, providing an efficient approach for natural compound-based cell reprogramming. English NATURE PUBLISHING GROUP BIOPHYSICAL REGULATION DIFFERENTIATION MECHANISM STATE MET Acceleration of somatic cell reprogramming into the induced pluripotent stem cell using a mycosporine-like amino acid, Porphyra 334 Article 10.1038/s41598-020-60680-5 1 SCIENTIFIC REPORTS, v.10, no.1 SCIENTIFIC REPORTS 10 1 scie scopus 000563054000011 2-s2.0-85080980826 Multidisciplinary Sciences Science & Technology - Other Topics Article BIOPHYSICAL REGULATION DIFFERENTIATION MECHANISM STATE MET