Rahman, Md. Ataur Rahman, Md Rezanur Zaman, Toyfiquz Uddin, Md. Sahab Islam, Rokibul Abdel-Daim, Mohamed M. Rhim, Hyewhon 2024-01-19T18:31:10Z 2024-01-19T18:31:10Z 2022-01-10 2020-01 1381-6128 https://pubs.kist.re.kr/handle/201004/119119 Background: Naturally-occurring products derived from living organisms have been shown to modulate various pharmacological and biological activities. Natural products protect against various diseases, which could be used for therapeutic assistance. Autophagy, a lysosome-mediated self-digestion pathway, has been implicated in a range of pathophyaiological conditions and has recently gained attention for its role in several neurodegenerative diseases. Methods: fn this current review, we emphasized the recent progress made in our understanding of the molecular mechanism of autophagy in different cellular and mouse models using naturally-occurring autophagy modulators for the management of several neuroclegenerative diseases. Resul&c: Accumulating evidence has- revealed that a wide variety of natural compounds such as alkaloids, polyphenols, terpenoids. xanthonoids, flavonoids, lignans, disaccharides. glycolipoproteins, and saponins are involved in the modulation of the autophagy signaling pathway. These natural products have been used to treat various neurodegenerative diseases such as Alzheimer's disease. Parkinson's disease. Huntington's disease, Amyotrophic lateral sclerosis, spinocerebellar ataxia, neuroblastoma, and glioblastoma. Although a number of synthetic autophagy regulators have been recognized as encouraging neurodegenerative therapeutic candidates, natural autophagy-regulating compounds have been of further interest as potential disease therapeutics, as they cause insignificant side effects. Conclusion: Existing in vitro and in vivo data are promising and highlight that naturally-occurring autophagyregulating compounds play an important role in the prevention and treatment of neurodegenerative disorders. English Bentham Science Publishers Emerging Potential of Naturally Occurring Autophagy Modulators Against Neurodegeneration Article 10.2174/1381612826666200107142541 1 Current Pharmaceutical Design, v.26, no.7, pp.772 - 779 Current Pharmaceutical Design 26 7 772 779 N scie scopus 000521826200007 2-s2.0-85082634795 Pharmacology & Pharmacy Pharmacology & Pharmacy Review SH-SY5Y NEUROBLASTOMA-CELLS ALPHA-SYNUCLEIN SIGNALING PATHWAYS MUTANT HUNTINGTIN MOUSE MODEL PARKINSONS-DISEASE INDUCED APOPTOSIS RESVERATROL INDUCTION DEGRADATION Natural products autophagy neurodegeneration therapeutic potential glycolipoproteins lignans