Lee, So-Yeon Park, No-June Jegal, Jonghwan Jo, Beom-Geun Choi, Sangho Lee, Sang Woo Uddin, Md. Salah Kim, Su-Nam Yang, Min Hye 2024-01-19T18:31:40Z 2024-01-19T18:31:40Z 2021-09-05 2020-01 2072-6643 https://pubs.kist.re.kr/handle/201004/119146 Wikstroemia indica (L.) C.A. Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the effects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of W. indica ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at a W. indica concentration of 1%. Furthermore, W. indica also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that W. indica has potential as a topical treatment for AD and as an adjunctive agent to control AD. English MDPI INTERFERON-GAMMA DERMATITIS BARRIER PIMECROLIMUS EXPRESSION CHILDREN AGENTS ROOTS IL-4 Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract Article 10.3390/nu12010173 1 NUTRIENTS, v.12, no.1 NUTRIENTS 12 1 scie scopus 000516825500173 2-s2.0-85077865848 Nutrition & Dietetics Nutrition & Dietetics Article INTERFERON-GAMMA DERMATITIS BARRIER PIMECROLIMUS EXPRESSION CHILDREN AGENTS ROOTS IL-4 Wikstroemia indica 2 4-dinitrochlorobenzene atopic dermatitis transepidermal water loss interleukin