Jana, Batakrishna Kim, Seongchan Choi, Huyeon Jin, Seongeon Kim, Kibeom Kim, Minsoo Lee, Hyojin Lee, Kwan Hyi Lee, Jungmin Park, Myoung-Hwan Jeong, Youngdo Ryu, Ja-Hyoung Kim, Chaekyu 2024-01-19T18:31:44Z 2024-01-19T18:31:44Z 2021-09-05 2020-01 1226-086X https://pubs.kist.re.kr/handle/201004/119151 Despite the extended use of cationic gold nanoparticles (AuNPs) in biomedical applications, direct one-pot synthesis of AuNPs with tunable size in aqueous media is limited due to the deleterious electrostatic attraction between AuCl4-anions and positively charged ligands. This paper describes the one-pot synthesis of cationic gold nanoparticles with size tunability based on host-guest chemistry. As the host molecule, cucurbit[7]uril inhibits self-aggregation in aqueous solution by threading positively charged guest ligands, which provides a shielding effect on the ligands. Reduction of the mixtures by directly adding NaBH4 generates cationic AuNPs with narrow size distributions. Furthermore, their potential in biomedical applications is demonstrated by siRNA transfection experiments. This approach relying on supramolecular-mediated interactions may provide new insights into organic/inorganic reactions that involve electrostatic disturbance. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. English 한국공업화학회 Supramolecular protection-mediated one-pot synthesis of cationic gold nanoparticles Article 10.1016/j.jiec.2019.09.018 1 Journal of Industrial and Engineering Chemistry, v.81, pp.303 - 308 Journal of Industrial and Engineering Chemistry 81 303 308 N scie scopus kci ART002553238 000501660000031 2-s2.0-85072601665 Chemistry, Multidisciplinary Engineering, Chemical Chemistry Engineering Article SIZE TRANSFECTION DNA OPPORTUNITIES CELLS Supramolecular chemistry Host-guest chemistry Gold nanoparticle Cucurbituril