Park, DoYeun Lee, Jaeseo Chung, Justin J. Jung, Youngmee Kim, Soo Hyun 2024-01-19T18:31:46Z 2024-01-19T18:31:46Z 2021-09-05 2020-01 0167-7799 https://pubs.kist.re.kr/handle/201004/119153 Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research. English Elsevier BV Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation Article 10.1016/j.tibtech.2019.06.006 1 Trends in Biotechnology, v.38, no.1, pp.99 - 112 Trends in Biotechnology 38 1 99 112 N scie scopus 000503376700010 2-s2.0-85069738845 Biotechnology & Applied Microbiology Biotechnology & Applied Microbiology Review CELL-DERIVED CARDIOMYOCYTES LONG-TERM COCULTURE A-CHIP MICROPHYSIOLOGICAL SYSTEMS HUMAN INTESTINE TISSUE MODEL DRUG LIVER NETWORK CULTURE innervation-on-a-chip integrated organ-on-a-chip multiplexing organ-on-chip scaling rules vascularization-on-a-chip