Lee, Sang Jin Jo, Ha Hyeon Lim, Kyung Seob Lim, Dohyung Lee, Soojin Lee, Jun Hee Kim, Wan Doo Jeong, Myung Ho Lim, Joong Yeon Kwon, Il Keun Jung, Youngmee Park, Jun-Kyu Park, Su A. 2024-01-19T18:32:30Z 2024-01-19T18:32:30Z 2021-09-05 2019-12-15 1385-8947 https://pubs.kist.re.kr/handle/201004/119196 In the last decade, stent implantation therapy has been widely performed in the clinic. Although the patient's cardiovascular state depends on their age, gender, and health condition, the development of customized individual stents has been limited. Thus, a patient-specific stent manufacturing system should be devised for more successful stent therapy. In this study, we prepared a 3D printed PLA biodegradable polymeric stent using polydopamine (PDA), polyethyleneimine (PEI) and heparin (Hep) chemistry to prevent restenosis and thrombosis with anticoagulation and good blood compatibility. Physico-chemical characterization indicated that pristine PLA substrates were well modified as the amine abundant surface allowed for coating of a large amount of Hep. From in vitro and ex vivo analysis, heparinized 3D PLA stents showed excellent thromboresistance and hemocompatibility functions as well as modulation of smooth muscle cell (SMC) and endothelial cell (EC) proliferation. In an in vivo study, the heparinized 3D PLA stent showed the widest lumen area with the least neointimal hyperplasia and without atherosclerosis or thrombosis. All of these assessments clearly confirmed that our innovative strategy may suggest a useful paradigm as a preparation method for a patient-customized fully biodegradable individual stent for successful implantation therapy. This would find wide utilization for cardiovascular clinical applications. English ELSEVIER SCIENCE SA DRUG-ELUTING STENTS IN-VIVO DEGRADATION BARE METAL STENT MECHANICAL-PROPERTIES BIORESORBABLE SCAFFOLDS COVALENT IMMOBILIZATION CELL-PROLIFERATION COATED STENT RESTENOSIS POLYDOPAMINE Heparin coating on 3D printed poly (l-lactic acid) biodegradable cardiovascular stent via mild surface modification approach for coronary artery implantation Article 10.1016/j.cej.2019.122116 1 CHEMICAL ENGINEERING JOURNAL, v.378 CHEMICAL ENGINEERING JOURNAL 378 scie scopus 000487764800049 2-s2.0-85068882522 Engineering, Environmental Engineering, Chemical Engineering Article DRUG-ELUTING STENTS IN-VIVO DEGRADATION BARE METAL STENT MECHANICAL-PROPERTIES BIORESORBABLE SCAFFOLDS COVALENT IMMOBILIZATION CELL-PROLIFERATION COATED STENT RESTENOSIS POLYDOPAMINE Biodegradable cardiovascular stent 3D printing Polylactic acid Polydopamine Heparin