Park, Jinyoung Cho, Jinhong Kim, Eunice EunKyeong Song, Eun Joo 2024-01-19T18:33:32Z 2024-01-19T18:33:32Z 2021-09-05 2019-12 1661-6596 https://pubs.kist.re.kr/handle/201004/119256 Mitosis is a complex and dynamic process that is tightly regulated by a large number of mitotic proteins. Dysregulation of these proteins can generate daughter cells that exhibit genomic instability and aneuploidy, and such cells can transform into tumorigenic cells. Thus, it is important for faithful mitotic progression to regulate mitotic proteins at specific locations in the cells at a given time in each phase of mitosis. Ubiquitin-dependent modifications play critical roles in this process by regulating the degradation, translocation, or signal transduction of mitotic proteins. Here, we review how ubiquitination and deubiquitination regulate the progression of mitosis. In addition, we summarize the substrates and roles of some deubiquitinating enzymes (DUBs) crucial for mitosis and describe how they contribute error correction during mitosis and control the transition between the mitotic phases. English MDPI NF-KAPPA-B ANAPHASE-PROMOTING COMPLEX CHROMOSOMAL PASSENGER COMPLEX SPINDLE-ASSEMBLY CHECKPOINT SMALL-MOLECULE INHIBITOR AURORA-B MITOTIC CHROMOSOMES CELL-PROLIFERATION DYNAMIC REGULATION UBIQUITIN CHAINS Deubiquitinating Enzymes: A Critical Regulator of Mitosis Article 10.3390/ijms20235997 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.20, no.23 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 23 scie scopus 000504428300179 2-s2.0-85075743195 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review NF-KAPPA-B ANAPHASE-PROMOTING COMPLEX CHROMOSOMAL PASSENGER COMPLEX SPINDLE-ASSEMBLY CHECKPOINT SMALL-MOLECULE INHIBITOR AURORA-B MITOTIC CHROMOSOMES CELL-PROLIFERATION DYNAMIC REGULATION UBIQUITIN CHAINS mitosis ubiquitination deubiquitination cancer