Lee, Seung Hwan Choi, Nakwon Sung, Jong Hwan 2024-01-19T18:33:41Z 2024-01-19T18:33:41Z 2021-09-05 2019-12 1742-5255 https://pubs.kist.re.kr/handle/201004/119266 Introduction: After administration, a drug undergoes absorption, distribution, metabolism, and elimination (ADME) before exerting its effect on the body. The combination of these process yields the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of a drug. Although accurate prediction of PK and PD profiles is essential for drug development, conventional in vitro models are limited by their lack of physiological relevance. Recently, microtechnology-based in vitro model systems, termed 'organ-on-a-chip,' have emerged as a potential solution. Areas covered: Orally administered drugs are absorbed through the intestinal wall and transported to the liver before entering systemic circulation, which plays an important role in the PK and PD profiles. Recently developed, chip-based in vitro models can be useful models for simulating such processes and will be covered in this paper. Expert opinion: The potential of intestine-on-a-chip models combined with conventional PK-PD modeling has been demonstrated with promising preliminary results. However, there are several challenges to overcome. Development of the intestinal wall, integration of the gut microbiome, and the provision of an intestine-specific environment must be achieved to realize in vivo-like intestinal model and enhance the efficiency of drug development. English TAYLOR & FRANCIS LTD CELL-CULTURE ANALOG TOTAL BIOASSAY SYSTEM 3D HUMAN LIVER IN-VITRO DRUG PERMEABILITY MICROPHYSIOLOGICAL SYSTEMS HEPATIC-METABOLISM TRACT EPITHELIUM COCULTURE SYSTEM IRRITABLE-BOWEL Pharmacokinetic and pharmacodynamic insights from microfluidic intestine-on-a-chip models Article 10.1080/17425255.2019.1700950 1 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, v.15, no.12, pp.1005 - 1019 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 15 12 1005 1019 scie scopus 000501693100001 2-s2.0-85076443264 Biochemistry & Molecular Biology Pharmacology & Pharmacy Toxicology Biochemistry & Molecular Biology Pharmacology & Pharmacy Toxicology Review CELL-CULTURE ANALOG TOTAL BIOASSAY SYSTEM 3D HUMAN LIVER IN-VITRO DRUG PERMEABILITY MICROPHYSIOLOGICAL SYSTEMS HEPATIC-METABOLISM TRACT EPITHELIUM COCULTURE SYSTEM IRRITABLE-BOWEL Pharmacokinetics pharmacodynamics organ-on-a chip multi-organ-on-a-chip (MOC) intestine-on-a-chip gut-on-a-chip