Yang, Yoosoo Nam, Gi-Hoon Kim, Gi Beom Kim, Yoon Kyoung Kim, In-San 2024-01-19T19:00:53Z 2024-01-19T19:00:53Z 2021-09-05 2019-11 0169-409X https://pubs.kist.re.kr/handle/201004/119371 Immunotherapy is revolutionizing the treatment of cancer, and the current immunotherapeutics have remarkably improved the outcomes for some cancer patients. However, we still need answers for patients with immunologically cold tumors that do not benefit from the current immunotherapy treatments. Here, we suggest a novel strategy that is based on using a very old and sophisticated system for cancer immunotherapy, namely "intrinsic cancer vaccination", which seeks to awaken our own immune system to activate tumor-specific T cells. To do this, we must take advantage of the genetic instability of cancer cells and the expression of cancer cell neoantigens to trigger immunity against cancer cells. It will be necessary to not only enhance the phagocytosis of cancer cells by antigen presenting cells but also induce immunogenic cancer cell death and the subsequent immunogenic clearance, cross-priming and generation of tumor-specific T cells. This strategy will allow us to avoid using known tumor-specific antigens, ex vivo manipulation or adoptive cell therapy; rather, we will efficiently present cancer cell neoantigens to our immune system and propagate the cancer-immunity cycle. This strategy simply follows the natural cycle of cancer-immunity from its very first step, and therefore could be combined with any other treatment modality to yield enhanced efficacy. (C) 2019 Elsevier B.V. All rights reserved. English ELSEVIER IMMUNOGENIC CELL-DEATH BACILLUS-CALMETTE-GUERIN MHC CLASS-I MITOCHONDRIAL TRANSCRIPTION FACTOR PATTERN-RECOGNITION RECEPTORS IMMUNE CHECKPOINT BLOCKADE MEMORY T-CELLS DENDRITIC CELLS TUMOR MICROENVIRONMENT CALRETICULIN EXPOSURE Intrinsic cancer vaccination Article 10.1016/j.addr.2019.05.007 1 ADVANCED DRUG DELIVERY REVIEWS, v.151, pp.2 - 22 ADVANCED DRUG DELIVERY REVIEWS 151 2 22 scie scopus 000502893600002 2-s2.0-85066282833 Pharmacology & Pharmacy Pharmacology & Pharmacy Review IMMUNOGENIC CELL-DEATH BACILLUS-CALMETTE-GUERIN MHC CLASS-I MITOCHONDRIAL TRANSCRIPTION FACTOR PATTERN-RECOGNITION RECEPTORS IMMUNE CHECKPOINT BLOCKADE MEMORY T-CELLS DENDRITIC CELLS TUMOR MICROENVIRONMENT CALRETICULIN EXPOSURE Cancer immunotherapy Immunogenic cell death Phagocytosis Immune checkpoint blockade