Heo, Gyu Seong Cho, Sangho Wooley, Karen L. 2024-01-19T19:00:55Z 2024-01-19T19:00:55Z 2021-09-05 2019-11 1598-5032 https://pubs.kist.re.kr/handle/201004/119374 ABA-type polycarbonate block copolymers with pendant vinyl ether and benzyl functionalities were synthesized by sequential ring-opening polymerization of functional cyclic carbonate monomers using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an organobase catalyst. The vinyl ether moieties on the resulting block copolymers were readily conjugated with 3-mercaptopropionic acid, cysteamine hydrochloride, and L-cysteine hydrochloride monohydrate through thiol-ene "click" reactions, yielding anionic, cationic, and zwitterionic self-assembled nanoparticles, respectively, in corresponding buffers. The effect of pH on the size and surface charge of nanoparticles were examined. English POLYMER SOC KOREA CHEMICAL DESIGN CANCER Preparation of Degradable Polymeric Nanoparticles with Various Sizes and Surface Charges from Polycarbonate Block Copolymers Article 10.1007/s13233-020-8044-x 1 MACROMOLECULAR RESEARCH, v.27, no.11, pp.1173 - 1178 MACROMOLECULAR RESEARCH 27 11 1173 1178 scie scopus kci ART002523585 000492339400001 2-s2.0-85074430198 Polymer Science Polymer Science Article CHEMICAL DESIGN CANCER degradable polymeric nanoparticles polycarbonates click chemistry charged micelles