Ahn, Hong Ryul Yang, Jae Wook Kim, Jee Young Lee, Chang Yong Kim, Tae-Jin Jung, Sang Hoon 2024-01-19T19:01:29Z 2024-01-19T19:01:29Z 2021-09-04 2019-11 1661-6596 https://pubs.kist.re.kr/handle/201004/119405 The aim of this study was to evaluate the pharmacological efficacy of persimmon leaves in two glaucoma models, microbeads-induced ocular hypertension (OHT) and DBA/2 mouse. Thus, we demonstrated that Ethanol Extract of Diospyros kaki (EEDK) reduced elevated intraocular pressure (IOP) in both mouse models of glaucoma by measurements with a tonometer. In particular, we revealed that retinal ganglion cell loss and optic nerve damage caused by IOP elevation were markedly diminished as assessed by TUNEL assay, H&E staining, and fluorescent staining, while the expression of soluble guanylate cyclase (sGC alpha -1) increased, when EEDK was administered, as revealed by western blot. Moreover, the b-wave magnitude indicating functional scotopic vision was significantly improved in EEDK-administered DBA/2 mice during the 10-week follow-up study, as observed with electroretinography. Collectively, our results suggested that EEDK could be an effective therapeutic and IOP-lowering agent for preventing and treating retinal degenerative diseases such as glaucoma. English MDPI OPEN-ANGLE GLAUCOMA OCULAR HYPERTENSION PROSTAGLANDIN ANALOGS EFFICACY DEATH The Intraocular Pressure-Lowering Effect of Persimmon leaves (Diospyros kaki) in a Mouse Model of Glaucoma Article 10.3390/ijms20215268 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.20, no.21 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 21 scie scopus 000498946100026 2-s2.0-85074175769 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article OPEN-ANGLE GLAUCOMA OCULAR HYPERTENSION PROSTAGLANDIN ANALOGS EFFICACY DEATH persimmon leaves ocular hypertension intraocular pressure soluble guanylate cyclase glaucoma