Lee, Yu Ra Lew, Bark Lynn Sim, Woo Young Lee, Jeongae Hong, Jongki Chung, Bong Chul 2024-01-19T19:01:43Z 2024-01-19T19:01:43Z 2021-09-04 2019-11 0385-2407 https://pubs.kist.re.kr/handle/201004/119418 Hair follicles are among the most highly proliferative tissues. Polyamines are associated with proliferation, and several polyamines including spermidine and spermine play anti-inflammatory roles. Androgenic alopecia results from increased dihydrotestosterone metabolism, and alopecia areata is an autoimmune disease. This study aimed to investigate differences in polyamine profiles in hair samples between patients with androgenic alopecia and alopecia areata. Polyamine concentrations were determined through high-performance liquid chromatography-mass spectrometry. Hair samples were derivatized with isobutyl chloroformate. Differences in polyamine levels were observed between androgenic alopecia and alopecia areata compared with normal controls. In particular, polyamine levels were higher in alopecia areata patients than in normal controls. Certain polyamines displayed different concentrations between the androgenic alopecia and alopecia areata groups, suggesting that some polyamines, particularly N-acetyl putrescine (P = 0.007) and N-acetyl cadaverine (P = 0.0021), are significantly different in androgenic alopecia. Furthermore, spermidine (P = 0.021) was significantly different in alopecia areata. Our findings suggest that non-invasive quantification of hair polyamines may help distinguish between androgenic alopecia and alopecia areata. Our study provides novel insights into physiological alterations in patients with androgenic alopecia and those with alopecia areata and reveals some differences in polyamine levels in hair loss diseases with two different modes of action. English WILEY MALE-PATTERN BALDNESS FOLLICLE FUNCTION OXIDASE ACTIVITY PLASMA GROWTH TESTOSTERONE DERIVATIVES INHIBITION MODULATION DISEASE Altered polyamine profiling in the hair of patients with androgenic alopecia and alopecia areata Article 10.1111/1346-8138.15063 1 JOURNAL OF DERMATOLOGY, v.46, no.11, pp.985 - 992 JOURNAL OF DERMATOLOGY 46 11 985 992 scie scopus 000484062500001 2-s2.0-85071569860 Dermatology Dermatology Article MALE-PATTERN BALDNESS FOLLICLE FUNCTION OXIDASE ACTIVITY PLASMA GROWTH TESTOSTERONE DERIVATIVES INHIBITION MODULATION DISEASE alopecia areata androgenic alopecia autoimmune disease hair follicle polyamine