Aslam, Adil S. Fuwad, Ahmed Ryu, Hyunil Selvaraj, Baskar Song, Jae-Won Kim, Dae Won Kim, Sun Min Lee, Jae Wook Jeon, Tae-Joon Cho, Dong-Gyu 2024-01-19T19:02:35Z 2024-01-19T19:02:35Z 2022-01-10 2019-10-04 1523-7060 https://pubs.kist.re.kr/handle/201004/119467 Cl--ion transporters (2a-2h) were synthesized based on the binding motifs of prodigiosin. Transporter 2e clearly displays Cl--ion transportation activity across both model and live cell membranes. Furthermore, 2e can disrupt Ca2+ homeostasis and increase the intracellular concentration of Ca2+ in the DLD-1 cell. This disruption can lead to Caspase-dependent apoptosis supported by CHOP expression (a marker of ER stress) and the appearance of the cleaved forms of Caspase 3 and PARP. English AMER CHEMICAL SOC CELL-DEATH APOPTOSIS BINDING CALCIUM Synthetic Anion Transporters as Endoplasmic Reticulum (ER) Stress Inducers Article 10.1021/acs.orglett.9b02823 1 ORGANIC LETTERS, v.21, no.19, pp.7828 - 7832 ORGANIC LETTERS 21 19 7828 7832 scie scopus 000489200100031 2-s2.0-85072656803 Chemistry, Organic Chemistry Article CELL-DEATH APOPTOSIS BINDING CALCIUM