Park, Jooho Choi, Yongwhan Chang, Hyeyoun Um, Wooram Ryu, Ju Hee Kwon, Ick Chan 2024-01-19T19:03:29Z 2024-01-19T19:03:29Z 2021-09-05 2019-10 1838-7640 https://pubs.kist.re.kr/handle/201004/119519 The use of nanomedicine for cancer treatment takes advantage of its preferential accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The development of cancer nanomedicine has promised highly effective treatment options unprecedented by standard therapeutics. However, the therapeutic efficacy of passively targeted nanomedicine is not always satisfactory because it is largely influenced by the heterogeneity of the intensity of the EPR effect exhibited within a tumor, at different stages of a tumor, and among individual tumors. In addition, limited data on EPR effectiveness in human hinders further clinical translation of nanomedicine. This unsatisfactory therapeutic outcome in mice and humans necessitates novel approaches to improve the EPR effect. This review focuses on current attempts at overcoming the limitations of traditional EPR-dependent nanomedicine by incorporating supplementary strategies, such as additional molecular targeting, physical alteration, or physiological remodeling of the tumor microenvironment. This review will provide valuable insight to researchers who seek to overcome the limitations of relying on the EPR effect alone in cancer nanomedicine and go "beyond the EPR effect". English IVYSPRING INT PUBL TARGETED PHOTODYNAMIC THERAPY IN-VIVO MACROMOLECULAR THERAPEUTICS MAGNETIC NANOPARTICLES CANCER NANOMEDICINE DELIVERY ANGIOGENESIS CHEMOTHERAPY GROWTH MECHANISMS Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment Article 10.7150/thno.37198 1 THERANOSTICS, v.9, no.26, pp.8073 - 8090 THERANOSTICS 9 26 8073 8090 scie scopus 000492831200007 2-s2.0-85074358341 Medicine, Research & Experimental Research & Experimental Medicine Review TARGETED PHOTODYNAMIC THERAPY IN-VIVO MACROMOLECULAR THERAPEUTICS MAGNETIC NANOPARTICLES CANCER NANOMEDICINE DELIVERY ANGIOGENESIS CHEMOTHERAPY GROWTH MECHANISMS EPR effect targeted therapy nanoparticle cancer treatment drug delivery