Bang, Seokyoung Jeong, Sohyeon Choi, Nakwon Kim, Hong Nam 2024-01-19T19:30:51Z 2024-01-19T19:30:51Z 2021-09-05 2019-09 1932-1058 https://pubs.kist.re.kr/handle/201004/119639 Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of human tissue on an engineered platform. In the case of brain tissue, structural connections and cell-cell interactions are important factors for brain function. The recent development of brain-on-a-chip is an effort to mimic those structural and functional aspects of brain tissue within a miniaturized engineered platform. From this perspective, we provide an overview of trace of brain-on-a-chip development, especially in terms of complexity and high-content/ high-throughput screening capabilities, and future perspectives on more in vivo-like brain-on-a-chip development. Published under license by AIP Publishing. English AMER INST PHYSICS IN-VITRO ENDOTHELIAL-CELLS ALZHEIMERS-DISEASE BARRIER PROPERTIES CULTURE PLATFORM ANIMAL-MODELS NETWORKS NEURONS RECONSTRUCTION REGENERATION Brain-on-a-chip: A history of development and future perspective Article 10.1063/1.5120555 1 BIOMICROFLUIDICS, v.13, no.5 BIOMICROFLUIDICS 13 5 scie scopus 000508187500001 2-s2.0-85073243143 Biochemical Research Methods Biophysics Nanoscience & Nanotechnology Physics, Fluids & Plasmas Biochemistry & Molecular Biology Biophysics Science & Technology - Other Topics Physics Article IN-VITRO ENDOTHELIAL-CELLS ALZHEIMERS-DISEASE BARRIER PROPERTIES CULTURE PLATFORM ANIMAL-MODELS NETWORKS NEURONS RECONSTRUCTION REGENERATION