Cha, Kwang Hyun Kim, Kyung-A Kang, Suk Woo Alam, Seemi Tasnim Jin, Jong Beom Yoo, Gyhye Jung, Sang Hoon Pan, Cheol-Ho Kang, Kyungsu 2024-01-19T19:30:55Z 2024-01-19T19:30:55Z 2021-09-04 2019-09 1756-4646 https://pubs.kist.re.kr/handle/201004/119643 Phytoestrogen is considered a promising natural remedy for various postmenopausal symptoms. However, most studies have focused on common soybean, Glycine max. Here, for the first time, we evaluated the in vivo effect of a distinct species, small black bean (Rhynchosia volubilis), on ovariectomized mice and investigated its impact on the intestinal microbiota and metabolic status. Ovariectomized mice exhibited significant body weight gain, a typical postmenopausal symptom, and microbial changes, such as decreased alpha-diversity; changes in microbial composition, especially abundances of the families Desulfovibrionaceae and Mogibacteriaceae and genus Dorea; and decreased amino acid and short-chain fatty acid levels. Administration of small black bean extract restores body weight and gut microbial perturbation to levels similar to those observed under normal conditions. Our data suggest that small black bean extract is a potential candidate functional food for treating postmenopausal symptoms via remodeling of the intestinal microbiome. English ELSEVIER SOY ISOFLAVONES ESTROGEN PHYTOESTROGENS PROGESTERONE METAANALYSIS PROTEIN EXERTS SEEDS Small black bean (Rhynchosia volubilis) extract ameliorates gut microbial and metabolic perturbation in ovariectomized mice Article 10.1016/j.jff.2019.103415 1 JOURNAL OF FUNCTIONAL FOODS, v.60 JOURNAL OF FUNCTIONAL FOODS 60 scie scopus 000478858700015 2-s2.0-85067202395 Food Science & Technology Nutrition & Dietetics Food Science & Technology Nutrition & Dietetics Article SOY ISOFLAVONES ESTROGEN PHYTOESTROGENS PROGESTERONE METAANALYSIS PROTEIN EXERTS SEEDS Gut microbiome Intestinal metabolite Ovariectomy Phytoestrogen Rhynchosia volubilis