Abuzar, Sharif Md Ahn, Jun-Hyun Park, Kyung Su Park, Eun Jung Baik, Seung Hyuk Hwang, Sung-Joo 2024-01-19T19:31:57Z 2024-01-19T19:31:57Z 2022-01-25 2019-08 1999-4923 https://pubs.kist.re.kr/handle/201004/119701 Colorectal cancer (CRC) is one of the most malignant and fatal cancers worldwide. Although cytoreductive surgery combined with chemotherapy is considered a promising therapy, peritoneal adhesion causes further complications after surgery. In this study, oxaliplatin-loaded Poly-(D,L-lactide-co-glycolide) (PLGA) microparticles were prepared using a double emulsion method and loaded into hyaluronic acid (HA)- and carboxymethyl cellulose sodium (CMCNa)-based cross-linked (HC) hydrogels. From characterization and evaluation study PLGA microparticles showed smaller particle size with higher entrapment efficiency, approximately 1100.4 +/- 257.7 nm and 77.9 +/- 2.8%, respectively. In addition, microparticle-loaded hydrogels showed more sustained drug release compared to the unloaded microparticles. Moreover, in an in vivo pharmacokinetic study after intraperitoneal administration in rats, a significant improvement in the bioavailability and the mean residence time of the microparticle-loaded hydrogels was observed. In HC21 hydrogels, AUC(0-48h), C-max, and T-max were 16012.12 +/- 188.75 ng.h/mL, 528.75 +/- 144.50 ng/mL, and 1.5 h, respectively. Furthermore, experimental observation revealed that the hydrogel samples effectively protected injured tissues from peritoneal adhesion. Therefore, the results of the current pharmacokinetic study together with our previous report of the in vivo anti-adhesion efficacy of HC hydrogels demonstrated that the PLGA microparticle-loaded hydrogels offer novel therapeutic strategy for CRC treatment. English MDPI Pharmacokinetic Profile and Anti-Adhesive Effect of Oxaliplatin-PLGA Microparticle-Loaded Hydrogels in Rats for Colorectal Cancer Treatment Article 10.3390/pharmaceutics11080392 1 PHARMACEUTICS, v.11, no.8 PHARMACEUTICS 11 8 N scie scopus 000484515100021 2-s2.0-85071148577 Pharmacology & Pharmacy Pharmacology & Pharmacy Article PERITONEAL CARCINOMATOSIS BIODEGRADABLE POLY(LACTIDE-CO-GLYCOLIDE) HYALURONIC-ACID COMPOSITES PREVENTION ADHESION DELIVERY RELEASE ORIGIN oxaliplatin PLGA hydrogel intra-abdominal anti-adhesion barrier colorectal cancer