Shin, Hyogeun Son, Yoojin Chae, Uikyu Kim, Jeongyeon Choi, Nakwon Lee, Hyunjoo J. Woo, Jiwan Cho, Yakdol Yang, Soo Hyun Lee, C. Justin Cho, Il-Joo 2024-01-19T19:32:15Z 2024-01-19T19:32:15Z 2021-09-02 2019-08 2041-1723 https://pubs.kist.re.kr/handle/201004/119717 Investigation and modulation of neural circuits in vivo at the cellular level are very important for studying functional connectivity in a brain. Recently, neural probes with stimulation capabilities have been introduced, and they provided an opportunity for studying neural activities at a specific region in the brain using various stimuli. However, previous methods have a limitation in dissecting long-range neural circuits due to inherent limitations on their designs. Moreover, the large size of the previously reported probes induces more significant tissue damage. Herein, we present a multifunctional multi-shank MEMS neural probe that is monolithically integrated with an optical waveguide for optical stimulation, microfluidic channels for drug delivery, and microelectrode arrays for recording neural signals from different regions at the cellular level. In this work, we successfully demonstrated the functionality of our probe by confirming and modulating the functional connectivity between the hippocampal CA3 and CA1 regions in vivo. English Nature Publishing Group Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo Article 10.1038/s41467-019-11628-5 1 Nature Communications, v.10 Nature Communications 10 Y scie scopus 000482183300001 2-s2.0-85071294080 Multidisciplinary Sciences Science & Technology - Other Topics Article DELIVERY SYNAPTIC PLASTICITY OPTICAL CONTROL LOCAL CIRCUITS HIGH-DENSITY LARGE-SCALE SILICON OSCILLATIONS STIMULATION HIPPOCAMPUS