Chung, In Jae Jeon, Seong Ik Cha, Eui-Joon Byun, Youngro Kwon, Ick Chan Kim, Young Il Kim, Kwangmeyung Ahn, Cheol-Hee 2024-01-19T19:32:16Z 2024-01-19T19:32:16Z 2021-09-02 2019-08 1226-086X https://pubs.kist.re.kr/handle/201004/119718 MRI and NIRF multimodal imaging probe was fabricated and investigated. Glycol chitosan coated SPION was decorated by MMP-2 substrate conjugating BHQ-3 and Cy5.5 dye at each end (BCMG-SPION). NIRF signals were recovered in the presence of MMP-2 at a sub-nanomolar level. BCMG-SPION produced the maximum NIRF intensity at 48 h post injection in vivo. Evaluation of the BCMG-SPION in the tumor tissue by MRI showed that relative contrast enhancement was 34% higher than normal muscles. NIRF images of excised organs showed the highest NIRF signal in tumor and the intensity was at least 8 times higher than other organs. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. English 한국공업화학회 Activatable NIRF/MRI dual imaging probe using bio-inspired coating of glycol chitosan on superparamagnetic iron oxide nanoparticles Article 10.1016/j.jiec.2019.04.006 1 Journal of Industrial and Engineering Chemistry, v.76, pp.403 - 409 Journal of Industrial and Engineering Chemistry 76 403 409 N scie scopus kci ART002493011 000470939700036 2-s2.0-85064433062 Chemistry, Multidisciplinary Engineering, Chemical Chemistry Engineering Article FLUORESCENT NANOPARTICLES NANOCRYSTALS SYSTEM ACID In vivo dual imaging MRI Optical imaging Bio-inspired adhesion Iron oxide Nanoparticles