Lee, Soojung Hwang, Eunjin Lee, Mina Choi, Jee Hyun 2024-01-19T19:32:58Z 2024-01-19T19:32:58Z 2021-09-02 2019-08 1226-2560 https://pubs.kist.re.kr/handle/201004/119759 Absence seizures (AS) are generalized non-convulsive seizures characterized by a brief loss of consciousness and spike-and-wave discharges (SWD) in an electroencephalogram (EEG). A number of animal models have been developed to explain the mechanisms of AS, and thalamo-cortical networks are considered to be involved. However, the cortical foci have not been well described in mouse models of AS. This study aims to use a high density EEG in pathophysiologically different AS models to compare the spatiotemporal patterns of SWDs. We used two AS models: a pharmacologically induced model (gamma-hydroxybutyric acid, GHB model) and a transgenic model (phospholipase beta4 knock-out, PLC beta 4 model). The occurrences of SWDs were confirmed by thalamic recordings. The topographical analysis of SWDs showed that the onset and propagation patterns were markedly distinguishable between the two models. In the PLC beta 4 model, the foci were located within the somatosensory cortex followed by propagation to the frontal cortex, whereas in the GHB model, a majority of SWDs was initiated in the prefrontal cortex followed by propagation to the posterior cortex. In addition, in the GHB model, foci were also observed in other cortical areas. This observation indicates that different cortical networks are involved in the generation of SWDs across the two models. English KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE EPILEPSY NEURONS SLEEP NETWORK INHIBITION PATHOPHYSIOLOGY MECHANISMS SYNCHRONY CONSCIOUSNESS RECEPTORS Distinct Topographical Patterns of Spike-Wave Discharge in Transgenic and Pharmacologically Induced Absence Seizure Models Article 10.5607/en.2019.28.4.474 1 EXPERIMENTAL NEUROBIOLOGY, v.28, no.4, pp.474 - 484 EXPERIMENTAL NEUROBIOLOGY 28 4 474 484 scie scopus kci ART002501436 000488872800004 2-s2.0-85073365510 Medicine, Research & Experimental Neurosciences Research & Experimental Medicine Neurosciences & Neurology Article EPILEPSY NEURONS SLEEP NETWORK INHIBITION PATHOPHYSIOLOGY MECHANISMS SYNCHRONY CONSCIOUSNESS RECEPTORS Electroencephalogram Mice Absence seizure Spike-wave discharge