Nam, Min-Ho Han, Kyung-Seok Lee, Jaekwang Won, Woojin Koh, Wuhyun Bae, Jin Young Woo, Junsung Kim, Jayoung Kwong, Elliot Choi, Tae-Yong Chun, Heejung Lee, Seung Eun Kim, Sang-Bum Park, Ki Duk Choi, Se-Young Bae, Yong Chul Lee, C. Justin 2024-01-19T19:33:07Z 2024-01-19T19:33:07Z 2021-09-02 2019-07-30 2211-1247 https://pubs.kist.re.kr/handle/201004/119765 The underlying mechanisms of how positive emotional valence (e.g., pleasure) causes preference of an associated context is poorly understood. Here, we show that activation of astrocytic mu-opioid receptor (MOR) drives conditioned place preference (CPP) by means of specific modulation of astrocytic MOR, an exemplar endogenous Gi protein-coupled receptor (Gi-GPCR), in the CA1 hippocampus. Long-term potentiation (LTP) induced by a subthreshold stimulation with the activation of astrocytic MOR at the Schaffer collateral pathway accounts for the memory acquisition to induce CPP. This astrocytic MOR-mediated LTP induction is dependent on astrocytic glutamate released upon activation of the astrocytic MOR and the consequent activation of the presynaptic mGluR1. The astrocytic MOR-dependent LTP and CPP were recapitulated by a chemogenetic activation of astrocyte-specifically expressed Gi-DREADD hM4Di. Our study reveals that the transduction of inhibitory Gi-signaling into augmented excitatory synaptic transmission through astrocytic glutamate is critical for the acquisition of contextual memory for CPP. English CELL PRESS LONG-TERM POTENTIATION SYNAPTIC PLASTICITY TRANSMITTER RELEASE EXPRESSION NEURONS DOPAMINE MORPHINE STIMULATION MGLUR1 AMPA Activation of Astrocytic mu-Opioid Receptor Causes Conditioned Place Preference Article 10.1016/j.celrep.2019.06.071 1 CELL REPORTS, v.28, no.5, pp.1154 - + CELL REPORTS 28 5 1154 + scie scopus 000477811200006 2-s2.0-85069686415 Cell Biology Cell Biology Article LONG-TERM POTENTIATION SYNAPTIC PLASTICITY TRANSMITTER RELEASE EXPRESSION NEURONS DOPAMINE MORPHINE STIMULATION MGLUR1 AMPA astrocyte conditioned place preference hippocampus long-term potentiation opioid μ-opioid receptor