Jeon, Jin-Kyung Seo, Hyunseon Park, Jimin Son, Soo Ji Kim, Yeong Rim Kim, Eun Shil Park, Jong Woong Jung, Woong-Gyo Jeon, Hojeong Kim, Yu-Chan Seok, Hyun-Kwang Shin, Jae Ho Ok, Myoung-Ryul 2024-01-19T19:34:32Z 2024-01-19T19:34:32Z 2021-09-02 2019-07 1598-9623 https://pubs.kist.re.kr/handle/201004/119846 The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implants because the device loses its fixation strength before the fractured bone heals. This study suggests a new approach to overcome this hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is an essential process in early bone regeneration, a Mg implant coated with electrospun nanofibers containing nitric oxide (NO), which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to be stored on the NO donor-conjugated nanofiber coating, stably delivered, and released to the fractured bone tissue near the implanted sites. An in vitro corrosion test reveals no adverse effect of the released NO on the corrosion behavior of the Mg implant. Simultaneously, the optimal concentration level of NO released from the implant significantly enhances tube network formation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis can be accelerated by combining NO-releasing nanofibers with a Mg implant. With its proven feasibility, the proposed approach could be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fixation. English 대한금속·재료학회 Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers Article 10.1007/s12540-018-00232-9 1 Metals and Materials International, v.25, no.4, pp.1098 - 1107 Metals and Materials International 25 4 1098 1107 N scie scopus kci ART002482153 000473163200026 2-s2.0-85059594092 Materials Science, Multidisciplinary Metallurgy & Metallurgical Engineering Materials Science Metallurgy & Metallurgical Engineering Article ENDOTHELIAL GROWTH-FACTOR ANGIOGENESIS CORROSION ALLOYS BIOMATERIALS MECHANISMS CHEMISTRY BEHAVIOR BIOLOGY CELLS Nitric oxide Nanofiber Angiogenesis Biodegradable magnesium implant Bone regeneration