Ko, Jeong-Hyeon Yang, Min Hee Baek, Seung Ho Nam, Dongwoo Jung, Sang Hoon Ahn, Kwang Seok 2024-01-19T20:00:19Z 2024-01-19T20:00:19Z 2021-08-31 2019-07 0951-418X https://pubs.kist.re.kr/handle/201004/119867 Theacrine, a purine alkaloid structurally similar to caffeine, has recently become of interest as a potential therapeutic compound. Here, we investigated the antimetastatic potential of theacrine on human breast cancer MDA-MB-231 cells. We observed that theacrine can reverse epithelial-to-mesenchymal transition (EMT), which resulted in a decrease in the levels of mesenchymal markers (Fibronectin, Vimentin, N-cadherin, Twist, and Snail) and an increase in the levels of epithelial markers (Occludin and E-cadherin) in the cells. Additionally, theacrine attenuates TGF-beta-induced EMT, cell adhesion, migration, and invasion in MDA-MB-231 cells. Overall, our results suggest that theacrine may inhibit the breast cancer cell metastasis by reversing the EMT process. English WILEY ASSAMICA VAR.-KUCHA E-CADHERIN TGF-BETA METASTASIS Theacrine attenuates epithelial mesenchymal transition in human breast cancer MDA-MB-231 cells Article 10.1002/ptr.6389 1 PHYTOTHERAPY RESEARCH, v.33, no.7, pp.1934 - 1942 PHYTOTHERAPY RESEARCH 33 7 1934 1942 scie scopus 000477912800017 2-s2.0-85067395587 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article ASSAMICA VAR.-KUCHA E-CADHERIN TGF-BETA METASTASIS breast cancer EMT metastasis TGF-beta theacrine