Jang, Se-Young Murale, Dhiraj P. Kim, Anne Doyoung Lee, Jun-Seok 2024-01-19T20:00:39Z 2024-01-19T20:00:39Z 2021-09-02 2019-06-14 1439-4227 https://pubs.kist.re.kr/handle/201004/119886 With the rapid advances in single-molecule and live-cell imaging studies to investigate biological problems, the role of chemical probes to monitor reactions in a live cell has considerably increased. However, selective labeling of a target protein or a specific residue is highly challenging due to the high complexity of the biological system. In particular, biological macromolecules (such as proteins, DNA, or RNA) share many functional groups that potentially cross-react with exogenous chemical probes. Thus, there are high demands for perfect biocompatible reactions utilizing biologically unavailable chemistry. Metal-catalyzed reactions have been extensively investigated as synthetic methodology studies, including initial attempts in applying the chemistry in aqueous solutions in vitro or even in biological conditions. Herein, the latest developments and progress in metal-catalyzed bio-orthogonal reactions for biomolecule labeling are summarized. English WILEY-V C H VERLAG GMBH AZIDE-ALKYNE CYCLOADDITION METATHESIS ARYLATION REAGENTS CLEAVAGE CYSTEINE ACCESS Recent Developments in Metal-Catalyzed Bio-orthogonal Reactions for Biomolecule Tagging Article 10.1002/cbic.201900052 1 CHEMBIOCHEM, v.20, no.12, pp.1498 - 1507 CHEMBIOCHEM 20 12 1498 1507 scie scopus 000471712800003 2-s2.0-85064500386 Biochemistry & Molecular Biology Chemistry, Medicinal Biochemistry & Molecular Biology Pharmacology & Pharmacy Review AZIDE-ALKYNE CYCLOADDITION METATHESIS ARYLATION REAGENTS CLEAVAGE CYSTEINE ACCESS biocatalysis click chemistry conjugation cross-coupling organometallic catalysis