Jeun, Minhong Lee, Hyo Jeong Park, Sungwook Do, Eun-ju Choi, Jaewon Sung, You-Na Hong, Seung-Mo Kim, Sang-Yeob Kim, Dong-Hee Kang, Ja Young Son, Hye-Nam Joo, Jinmyoung Song, Eun Mi Hwang, Sung Wook Park, Sang Hyoung Yang, Dong-Hoon Ye, Byong Duk Byeon, Jeong-Sik Choe, Jaewon Yang, Suk-Kyun Moinova, Helen Markowitz, Sanford D. Lee, Kwan Hyi Myung, Seung-Jae 2024-01-19T20:00:44Z 2024-01-19T20:00:44Z 2021-09-02 2019-06-05 2198-3844 https://pubs.kist.re.kr/handle/201004/119891 Colorectal cancer (CRC) is the second-leading cause of cancer-related mortality worldwide, which may be effectively reduced by early screening. Colon cancer secreted protein-2 (CCSP-2) is a promising blood marker for CRC. An electric-field effect colorectal sensor (E-FECS), an ion-sensitive field-effect transistor under dual gate operation with nanostructure is developed, to quantify CCSP-2 directly from patient blood samples. The sensing performance of the E-FECS is verified in 7 controls and 7 CRC samples, and it is clinically validated on 30 controls, 30 advanced adenomas, and 81 CRC cases. The concentration of CCSP-2 is significantly higher in plasma samples from CRC and advanced adenoma compared with controls (both P < 0.001). Sensitivity and specificity for CRC versus controls are 44.4% and 86.7%, respectively (AUC of 0.67), and 43.3% and 86.7%, respectively, for advanced adenomas (AUC of 0.67). CCSP 2 detects a greater number of CRC cases than carcinoembryonic antigen does (45.6% vs 24.1%), and the combination of the two markers detects an even greater number of cases (53.2%). The E-FECS system successfully detects CCSP-2 in a wide range of samples including early stage cancers and advanced adenoma. CCSP-2 has potential for use as a blood-based biomarker for CRC. English WILEY COLONOSCOPY PREVENTION BIOSENSOR MARKERS RATES A Novel Blood-Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein-2 Article 10.1002/advs.201802115 1 ADVANCED SCIENCE, v.6, no.11 ADVANCED SCIENCE 6 11 scie scopus 000470189500015 2-s2.0-85064602319 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article COLONOSCOPY PREVENTION BIOSENSOR MARKERS RATES colorectal adenomas colorectal cancer colorectal cancer screening electric-field effect colorectal sensor tumor markers