Pentecost, Amanda Kim, Min Ju Jeon, Sangmin Ko, Young Ji Kwon, Ick Chan Gogotsi, Yury Kim, Kwangmeyung Spiller, Kara L. 2024-01-19T20:01:17Z 2024-01-19T20:01:17Z 2021-09-02 2019-06 2056-3418 https://pubs.kist.re.kr/handle/201004/119920 We previously demonstrated that octadecylamine-functionalized nanodiamond (ND-ODA) and dexamethasone (Dex)-adsorbed ND-ODA (ND-ODA-Dex) promoted anti-inflammatory and pro-regenerative behavior in human macrophages in vitro. In this study, we performed a pilot study to investigate if these immunomodulatory effects translate when used as a treatment for rheumatoid arthritis in mice. Following local injection in limbs of mice with collagen type II-induced arthritis, microcomputed tomography showed that mice treated with a low dose of ND-ODA and ND-ODA-Dex did not experience bone loss to the levels observed in non-treated arthritic controls. A low dose of ND-ODA and ND-ODA-Dex also reduced macrophage infiltration and expression of pro-inflammatory mediators iNOS and tumor necrosis factor-alpha compared to the arthritic control, while a high dose of ND-ODA increased expression of these markers. Overall, these results suggest that ND-ODA may be useful as an inherently immunomodulatory platform, and support the need for an in-depth study, especially with respect to the effects of dose. English OXFORD UNIV PRESS SYNOVIAL TISSUE MACROPHAGE NECROSIS-FACTOR-ALPHA PARTICLE-SIZE DEXAMETHASONE ACTIVATION RECEPTOR GLUCOCORTICOIDS INTERLEUKIN-10 NANOPARTICLES PHAGOCYTOSIS Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis Article 10.1093/rb/rbz012 1 REGENERATIVE BIOMATERIALS, v.6, no.3, pp.163 - 174 REGENERATIVE BIOMATERIALS 6 3 163 174 scie scopus 000482716500004 2-s2.0-85071148144 Materials Science, Biomaterials Materials Science Article SYNOVIAL TISSUE MACROPHAGE NECROSIS-FACTOR-ALPHA PARTICLE-SIZE DEXAMETHASONE ACTIVATION RECEPTOR GLUCOCORTICOIDS INTERLEUKIN-10 NANOPARTICLES PHAGOCYTOSIS drug delivery nanobiomaterials biomaterial-cell interaction