Lee, A-Young Kim, Kyoung-Ran Yu, Jeong Heon Ahn, Dae-Ro 2024-01-19T20:01:25Z 2024-01-19T20:01:25Z 2021-09-02 2019-06 1226-086X https://pubs.kist.re.kr/handle/201004/119928 Three dimensional DNA nanostructures are often limited in scalability due to low assembly yield at high concentrations, leaving themselves less suitable for industrial uses. To overcome this drawback, we here employed L-DNA duplex (L-ds) as a drug carrier. Due to its simple structure, L-ds can easily be prepared at micromolar concentrations without causing any considerable by-product, providing sufficient scalability for practical development. With sufficient cellular uptake efficiency in SCC7 cells and the tumor accumulation level in a SCC7-tumor xenograft mouse model, L-ds could well be utilized as a carrier for intracellular and tumor delivery of an anticancer agent, providing substantial cytotoxicity and inhibition of tumor growth, respectively. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. English 한국공업화학회 L-DNA linear duplex: An efficient drug delivery carrier with a simple structure Article 10.1016/j.jiec.2019.02.025 1 Journal of Industrial and Engineering Chemistry, v.74, pp.187 - 192 Journal of Industrial and Engineering Chemistry 74 187 192 N scie scopus kci ART002473683 000464486700021 2-s2.0-85062619392 Chemistry, Multidisciplinary Engineering, Chemical Chemistry Engineering Article L-DNA duplex Drug delivery Doxorubicin Anticancer therapy