Chu, Yeonjeong Shin, Min Chul Sung, June Park, Jongmin Kim, Eunha Lee, Sanghee 2024-01-19T20:01:33Z 2024-01-19T20:01:33Z 2021-09-02 2019-06 1043-1802 https://pubs.kist.re.kr/handle/201004/119934 Because mitochondria are essential organelles for regulating energy homeostasis and intrinsic apoptosis, the perturbation of mitochondrial functions has been considered as an anticancer treatment. In this study, a new near-infrared (NIR) fluorescent probe, SiR-Mitol 1 was developed as a theragnostic agent for brain tumor by targeting mitochondria. SiR-Mito11 exhibited potential anticancer activity against glioma cells but tolerance in normal neuronal cells. We further confirmed that the selective accumulation of SiR-Mitol 1 in glioma cells disrupted mitochondria membrane potential, followed by apoptotic cell death. English AMER CHEMICAL SOC CANCER APOPTOSIS DELIVERY BIOLOGY RELEASE Development of Theragnostic Tool Using NIR Fluorescence Probe Targeting Mitochondria in Glioma Cells Article 10.1021/acs.bioconjchem.9b00375 1 BIOCONJUGATE CHEMISTRY, v.30, no.6, pp.1642 - 1648 BIOCONJUGATE CHEMISTRY 30 6 1642 1648 scie scopus 000472679100007 2-s2.0-85067295822 Biochemical Research Methods Biochemistry & Molecular Biology Chemistry, Multidisciplinary Chemistry, Organic Biochemistry & Molecular Biology Chemistry Article CANCER APOPTOSIS DELIVERY BIOLOGY RELEASE