Kum, Jeungeun Kim, Jin Won Braubach, Oliver Ha, Jong-Gyun Cho, Hyung-Ju Kim, Chang-Noon Han, Hio-Been Choi, Jee Hyun Yoon, Joo-Heon 2024-01-19T20:02:20Z 2024-01-19T20:02:20Z 2021-09-02 2019-05-28 1662-4548 https://pubs.kist.re.kr/handle/201004/119975 Recent brain connectome studies have evidenced distinct and overlapping brain regions involved in processing olfactory perception. However, neural correlates of hypo- or anosmia in olfactory disorder patients are poorly known. Furthermore, the bottom-up and top-down processing of olfactory perception have not been well-documented, resulting in difficulty in locating the disease foci of olfactory disorder patients. The primary aim of this study is to characterize the bottom-up process of the neural dynamics across peripheral and central brain regions in anesthetized mice. We particularly focused on the neural oscillations of local field potential (LFP) in olfactory epithelium (OE), olfactory blub (OB), prefrontal cortex (PFC), and hippocampus (HC) during an olfactory oddball paradigm in urethane anesthetized mice. Odorant presentations evoked neural oscillations across slow and fast frequency bands including delta (1-4 Hz), theta (6-10 Hz), beta (15-30 Hz), low gamma (30-50 Hz), and high gamma (70-100 Hz) in both peripheral and central nervous systems, and the increases were more prominent in the infrequently presented odorant. During 5 s odorant exposures, the oscillatory responses in power were persistent in OE, OB, and PFC, whereas neural oscillations of HC increased only for short time at stimulus onset. These oscillatory responses in power were insignificant in both peripheral and central regions of the ZnSO4 -treated anosmia model. These results suggest that olfactory stimulation induce LFP oscillations both in the peripheral and central nervous systems and suggest the possibility of linkage of LFP oscillations in the brain to the oscillations in the peripheral olfactory system. English FRONTIERS MEDIA SA SMELL IDENTIFICATION TEST PARKINSONS-DISEASE ODOR DISCRIMINATION PENNSYLVANIA SMELL GAMMA-OSCILLATIONS DYSFUNCTION IMPAIRMENT MOUSE BULB BEHAVIOR Neural Dynamics of Olfactory Perception: Low- and High-Frequency Modulations of Local Field Potential Spectra in Mice Revealed by an Oddball Stimulus Article 10.3389/fnins.2019.00478 1 FRONTIERS IN NEUROSCIENCE, v.13 FRONTIERS IN NEUROSCIENCE 13 scie scopus 000469278700001 2-s2.0-85068552718 Neurosciences Neurosciences & Neurology Article SMELL IDENTIFICATION TEST PARKINSONS-DISEASE ODOR DISCRIMINATION PENNSYLVANIA SMELL GAMMA-OSCILLATIONS DYSFUNCTION IMPAIRMENT MOUSE BULB BEHAVIOR oddball paradigm local field potential neural oscillations olfaction attention anterior cingulate cortex primary olfactory cortex anterior olfactory