Kim, Ji-Won Lee, Sang Seok Park, Jinho Ku, Minhee Yang, Jaemoon Kim, Shin-Hyun 2024-01-19T20:02:22Z 2024-01-19T20:02:22Z 2021-09-02 2019-05-24 1613-6810 https://pubs.kist.re.kr/handle/201004/119978 Microcapsules with molecule-selective permeation are appealing as microreactors, capsule-type sensors, drug and cell carriers, and artificial cells. To accomplish molecular size-and charge-selective permeation, regular size of pores and surface charges have been formed in the membranes. However, it remains an important challenge to provide advanced regulation of transmembrane transport. Here, smart microcapsules are designed that provide molecular polarity-and temperature-dependent permeability. With capillary microfluidic devices, water-in-oil-in-water (W/O/W) double-emulsion drops are prepared, which serve as templates to produce microcapsules. The oil shell is composed of two monomers and dodecanol, which turns to a polymeric framework whose continuous voids are filled with dodecanol upon photopolymerization. One of the monomers provides mechanical stability of the framework, whereas the other serves as a compatibilizer between growing polymer and dodecanol, preventing macrophase separation. Above melting point of dodecanol, molecules that are soluble in the molten dodecanol are selectively allowed to diffuse across the shell, where the rate of transmembrane transport is strongly influenced by partition coefficient. The rate is drastically lowered for temperatures below the melting point. This molecular polarity-and temperature-dependent permeability renders the microcapsules potentially useful as drug carriers for triggered release and contamination-free microreactors and microsensors. English WILEY-V C H VERLAG GMBH INDUCED PHASE-SEPARATION SHELL DOUBLE EMULSIONS SEMIPERMEABLE MICROCAPSULES POLYELECTROLYTE MICROCAPSULES MICROFLUIDIC FABRICATION SELECTIVE PERMEABILITY POLYMER SIZE COLLOIDOSOMES NANOPARTICLES Smart Microcapsules with Molecular Polarity- and Temperature-Dependent Permeability Article 10.1002/smll.201900434 1 SMALL, v.15, no.21 SMALL 15 21 scie scopus 000468978300005 2-s2.0-85064652774 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article INDUCED PHASE-SEPARATION SHELL DOUBLE EMULSIONS SEMIPERMEABLE MICROCAPSULES POLYELECTROLYTE MICROCAPSULES MICROFLUIDIC FABRICATION SELECTIVE PERMEABILITY POLYMER SIZE COLLOIDOSOMES NANOPARTICLES microcapsules microfluidics phase-change materials selective permeation transmembrane transport