Sohn, Heesung Park, Mikyoung 2024-01-19T20:03:22Z 2024-01-19T20:03:22Z 2022-01-10 2019-05 0253-6269 https://pubs.kist.re.kr/handle/201004/120028 The -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a major glutamate-gated ion channel in the brain and is important for synaptic transmission, synaptic plasticity, and learning. Palmitoylation, a post-translational modification, is a critical process regulating AMPAR trafficking, synaptic function and plasticity, and learning and memory in health and diseases. In this review, we discuss current knowledge on the palmitoylation-dependent regulation of AMPAR trafficking and functions. We focus on the palmitoylation of AMPARs and other synaptic proteins that directly or indirectly interact with AMPARs, including postsynaptic density 95, glutamate receptor-interacting protein/AMPAR-binding protein, A-kinase anchoring protein 79/150, and protein interacting with C kinase 1. Finally, we discuss what future studies should address in the field of palmitoylation-dependent AMPAR trafficking and function with regard to physiology and neurodegenerative diseases. English PHARMACEUTICAL SOC KOREA ACTIVITY-DEPENDENT UBIQUITINATION DOMAIN-CONTAINING PROTEIN MOUSE MODEL DIFFERENTIAL PALMITOYLATION INTRACELLULAR TRAFFICKING PHOSPHORYLATION SITES POSTSYNAPTIC DENSITY GLUTAMATE RECEPTORS DUAL PALMITOYLATION SUBUNIT COMPOSITION Palmitoylation-mediated synaptic regulation of AMPA receptor trafficking and function Article 10.1007/s12272-019-01134-z 1 ARCHIVES OF PHARMACAL RESEARCH, v.42, no.5, pp.426 - 435 ARCHIVES OF PHARMACAL RESEARCH 42 5 426 435 scie scopus kci ART002473158 000467386600005 2-s2.0-85062671720 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Review ACTIVITY-DEPENDENT UBIQUITINATION DOMAIN-CONTAINING PROTEIN MOUSE MODEL DIFFERENTIAL PALMITOYLATION INTRACELLULAR TRAFFICKING PHOSPHORYLATION SITES POSTSYNAPTIC DENSITY GLUTAMATE RECEPTORS DUAL PALMITOYLATION SUBUNIT COMPOSITION AMPAR trafficking Palmitoylation Synapse Synaptic plasticity Synaptic proteins Neurodegenerative disease