Jo, Beom-Geun Park, No-June Jegal, Jonghwan Choi, Sangho Lee, Sang Woo Yi, Li Wan Kim, Su-Nam Yang, Min Hye 2024-01-19T20:03:27Z 2024-01-19T20:03:27Z 2021-09-02 2019-05 0032-0943 https://pubs.kist.re.kr/handle/201004/120033 Stellera chamaejasme, also known as "Langdu", has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7-O-glucoside, have a preventive effect on the development of atopic dermatitis in oxazolone-treated BALB/c mice and 2,4-dinitrochlorobenzene-treated hairless mice. The epicutaneous applications of oxazolone and 2,4-dinitrochlorobenzene evoke an experimental murine atopic dermatitis-like reaction in BALB/c mouse ears and SKH-1 hairless mice. Atopic skin symptoms, including erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and lichenification (skin thickening), responded to treatment with S. chamaejasme aerial parts EtOH extract for 2 or 3 weeks. Histopathological examination revealed S. chamaejasme aerial parts EtOH extract significantly reduced inflammatory cell infiltration when applied to atopic dermatitis mice. In addition, luteolin 7-O-glucoside, the major active compound of the S. chamaejasme aerial parts EtOH extract, decreased serum IgE and IL-4 levels and transepidermal water loss and increased skin hydration, therefore exhibiting strong anti-atopic dermatitis activity in 2,4-dinitrochlorobenzene-induced atopic dermatitis mice. In this study, we confirmed antipruritic and antidermatitic effects of S. chamaejasme extract and its main component luteolin 7-O-glucoside in atopic dermatitis murinemodels. The study shows S. chamaejasme aerial parts EtOH extract and luteolin 7-O-glucoside are most likely to be potential drug candidates for atopic dermatitis treatment. English GEORG THIEME VERLAG KG MEDICINAL-PLANTS NATURAL-PRODUCTS EXPRESSION INSIGHTS RISK Stellera chamaejasme and Its Main Compound Luteolin 7-O-Glucoside Alleviates Skin Lesions in Oxazolone- and 2,4-Dinitrochlorobenzene-Stimulated Murine Models of Atopic Dermatitis Article 10.1055/a-0746-8698 1 PLANTA MEDICA, v.85, no.7, pp.583 - 590 PLANTA MEDICA 85 7 583 590 scie scopus 000466934800009 2-s2.0-85059817787 Plant Sciences Chemistry, Medicinal Integrative & Complementary Medicine Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Integrative & Complementary Medicine Article MEDICINAL-PLANTS NATURAL-PRODUCTS EXPRESSION INSIGHTS RISK Stellera chamaejasme Thymelaeaceae luteolin 7-O-glucoside atopic dermatitis skin barrier function interleukin 4 immunoglobulin E