Koirala, Manoj Lee, Young Kee Kim, Min Seon Chung, You Chul Park, Jin-Soo Kim, Seung-Young 2024-01-19T20:03:49Z 2024-01-19T20:03:49Z 2021-09-02 2019-05 1934-578X https://pubs.kist.re.kr/handle/201004/120054 In this study, a whole-cell biotransformation by Bacillus amyloliquefaciens Korean Collection for Type Culture 13588 was carried out to acquire naringenin derivatives. High-performance liquid chromatography analysis of the reaction metabolites showed the presence of 3 different products. The structure of the metabolites was confirmed through high-resolution quadrupole-time-of-flight electrospray-ionization mass spectrometry and nuclear magnetic resonance analysis. The result revealed that B. amyloliquefaciens catalyzes naringenin into 3 derivatives, naringenin 7-O-phosphate, naringenin 7-O-glucoside (prunin), and 6''-O-succinylprunin. To our knowledge, this is the first report of the production of 3 different derivatives when naringenin was used as a substrate. Furthermore, our study also revealed that the product naringenin 7-O-phosphate has approximately 45-fold higher water solubility than that of naringenin. Our finding suggests that biotransformation might solve the low bioavailability of flavonoids. English SAGE PUBLICATIONS INC ANTIBACTERIAL ACTIVITY BIOLOGICAL-PROPERTIES FLAVONOID NARINGENIN WATER-SOLUBILITY Biotransformation of Naringenin by Bacillus amyloliquefaciens Into Three Naringenin Derivatives Article 10.1177/1934578X19851971 1 NATURAL PRODUCT COMMUNICATIONS, v.14, no.5 NATURAL PRODUCT COMMUNICATIONS 14 5 scie scopus 000470131700071 2-s2.0-85066409755 Chemistry, Medicinal Food Science & Technology Pharmacology & Pharmacy Food Science & Technology Article ANTIBACTERIAL ACTIVITY BIOLOGICAL-PROPERTIES FLAVONOID NARINGENIN WATER-SOLUBILITY biotransformation Bacillus amyloliquefaciens naringenin derivatives water solubility