Hwang, Eunjin Brown, Ritchie E. Kocsis, Bernat Kim, Tae McKenna, James T. McNally, James M. Han, Hio-Been Choi, Jee Hyun 2024-01-19T20:03:54Z 2024-01-19T20:03:54Z 2021-09-02 2019-05 1863-2653 https://pubs.kist.re.kr/handle/201004/120058 High-density electroencephalographic (hdEEG) recordings are widely used in human studies to determine spatio-temporal patterns of cortical electrical activity. How these patterns of activity are modulated by subcortical arousal systems is poorly understood. Here, we couple selective optogenetic stimulation of a defined subcortical cell-type, basal forebrain (BF) parvalbumin (PV) neurons, with hdEEG recordings in mice (Opto-hdEEG). Stimulation of BF PV projection neurons preferentially generated time-locked gamma oscillations in frontal cortices. BF PV gamma-frequency stimulation potently modulated an auditory sensory paradigm used to probe cortical function in neuropsychiatric disorders, the auditory steady-state response (ASSR). Phase-locked excitation of BF PV neurons in advance of 40Hz auditory stimuli enhanced the power, precision and reliability of cortical responses, and the relationship between responses in frontal and auditory cortices. Furthermore, synchronization within a frontal hub and long-range cortical interactions were enhanced. Thus, phasic discharge of BF PV neurons changes cortical processing in a manner reminiscent of global workspace models of attention and consciousness. English SPRINGER HEIDELBERG SELECTIVE ATTENTION GAMMA RHYTHM ELECTROENCEPHALOGRAM INTERNEURONS SYNCHRONY FREQUENCY CIRCUIT SLEEP Optogenetic stimulation of basal forebrain parvalbumin neurons modulates the cortical topography of auditory steady-state responses Article 10.1007/s00429-019-01845-5 1 BRAIN STRUCTURE & FUNCTION, v.224, no.4, pp.1505 - 1518 BRAIN STRUCTURE & FUNCTION 224 4 1505 1518 scie scopus 000467618100009 2-s2.0-85062682731 Anatomy & Morphology Neurosciences Anatomy & Morphology Neurosciences & Neurology Article SELECTIVE ATTENTION GAMMA RHYTHM ELECTROENCEPHALOGRAM INTERNEURONS SYNCHRONY FREQUENCY CIRCUIT SLEEP Basal forebrain Parvalbumin Gamma oscillations Auditory steady-state response (ASSR) Optogenetic high-density EEG