Koo, Song Yi Hwang, Ji-Hyun Yang, Seung-Hoon Um, Jae-In Hong, Kwang Won Kang, Kyungsu Pan, Cheol-Ho Hwang, Keum Taek Kim, Sang Min 2024-01-19T20:04:15Z 2024-01-19T20:04:15Z 2021-08-31 2019-05 1660-3397 https://pubs.kist.re.kr/handle/201004/120078 Fucoxanthin (FX), a marine carotenoid found in macroalgae and microalgae, exhibits several beneficial effects to health. The anti-obesity activity of FX is well documented, but FX has not been mass-produced or applied extensively or commercially because of limited availability of raw materials and complex extraction techniques. In this study, we investigated the anti-obesity effect of standardized FX powder (Phaeodactylum extract (PE)) developed from microalga Phaeodactylum tricornutum as a commercial functional food. The effects of PE on adipogenesis inhibition in 3T3-L1 adipocytes and anti-obesity in high-fat diet (HFD)-fed C57BL/6J mice were evaluated. PE and FX dose-dependently decreased intracellular lipid contents in adipocytes without cytotoxicity. In HFD-fed obese mice, PE supplementation for six weeks decreased body weight, organ weight, and adipocyte size. In the serum parameter analysis, the PE-treated groups showed attenuation of lipid metabolism dysfunction and liver damage induced by HFD. In the liver, uncoupling protein-1 (UCP1) upregulation and peroxisome proliferator activated receptor (PPAR) downregulation were detected in the PE-treated groups. Additionally, micro computed tomography revealed lower fat accumulation in PE-treated groups compared to that in the HFD group. These results indicate that PE exerts anti-obesity effects by inhibiting adipocytic lipogenesis, inducing fat mass reduction and decreasing intracellular lipid content, adipocyte size, and adipose weight. English MDPI CONJUGATED LINOLEIC-ACID IMPROVES LIPID-METABOLISM BODY-WEIGHT GAIN ADIPOSE-TISSUE BLOOD-GLUCOSE OBESE SEAWEED COMBINATION MANAGEMENT MICE Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin Article 10.3390/md17050311 1 MARINE DRUGS, v.17, no.5 MARINE DRUGS 17 5 scie scopus 000470964600064 2-s2.0-85066283514 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article CONJUGATED LINOLEIC-ACID IMPROVES LIPID-METABOLISM BODY-WEIGHT GAIN ADIPOSE-TISSUE BLOOD-GLUCOSE OBESE SEAWEED COMBINATION MANAGEMENT MICE anti-obesity effect Phaeodactylum tricornutum fucoxanthin Phaeodactylum extract microalgae