Haque, Md. Mamunul Murale, Dhiraj P. Kim, Yun Kyung Lee, Jun-Seok 2024-01-19T20:04:57Z 2024-01-19T20:04:57Z 2021-09-02 2019-04-02 1661-6596 https://pubs.kist.re.kr/handle/201004/120114 Tauopathy is a collective term for neurodegenerative diseases associated with pathological modifications of tau protein. Tau modifications are mediated by many factors. Recently, reactive oxygen species (ROS) have attracted attention due to their upstream and downstream effects on tauopathy. In physiological conditions, healthy cells generate a moderate level of ROS for self-defense against foreign invaders. Imbalances between ROS and the anti-oxidation pathway cause an accumulation of excessive ROS. There is clear evidence that ROS directly promotes tau modifications in tauopathy. ROS is also highly upregulated in the patients' brain of tauopathies, and anti-oxidants are currently prescribed as potential therapeutic agents for tauopathy. Thus, there is a clear connection between oxidative stress (OS) and tauopathies that needs to be studied in more detail. In this review, we will describe the chemical nature of ROS and their roles in tauopathy. English MDPI TRANSGENIC MOUSE MODEL ALZHEIMERS-DISEASE FLUORESCENT-PROBE HYDROGEN-PEROXIDE SUPEROXIDE-DISMUTASE PARKINSONS-DISEASE MITOCHONDRIAL DYSFUNCTION A-BETA DEHYDROGENASE COMPLEX COGNITIVE IMPAIRMENT Crosstalk between Oxidative Stress and Tauopathy Article 10.3390/ijms20081959 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.20, no.8 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 8 scie scopus 000467648700157 2-s2.0-85065297601 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review TRANSGENIC MOUSE MODEL ALZHEIMERS-DISEASE FLUORESCENT-PROBE HYDROGEN-PEROXIDE SUPEROXIDE-DISMUTASE PARKINSONS-DISEASE MITOCHONDRIAL DYSFUNCTION A-BETA DEHYDROGENASE COMPLEX COGNITIVE IMPAIRMENT oxidative stress reactive oxygen species tauopathy