Ali, Eslam M. H. Abdel-Maksoud, Mohammed S. Oh, Chang-Hyun 2024-01-19T20:30:14Z 2024-01-19T20:30:14Z 2022-01-10 2019-04-01 0968-0896 https://pubs.kist.re.kr/handle/201004/120116 Thienopyrimidine scaffold is a fused heterocyclic ring system that structurally can be considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres. Thienopyrimidines exist in three distinct isomeric forms. The current review discusses thieno[2,3-d] pyrimidine as a one of the opulent heterocycles in drug discovery. Its broad range of medical applications such as anticancer, anti-inflammatory, anti-microbial, and CNS protective agents has inspired us to study its structure-activity relationship (SAR), along with its relevant synthetic strategies. The present review briefly summarizes synthetic approaches for the preparation of thieno[2,3-d] pyrimidine derivatives. In addition, the promising biological activities of this scaffold are also illustrated with explanatory diagrams for their SAR studies. English PERGAMON-ELSEVIER SCIENCE LTD RECEPTOR TYROSINE KINASE INITIATION-FACTOR 4E BIOLOGICAL EVALUATION DERIVATIVES BEARING ANTICANCER ACTIVITY 3-D PYRIMIDINE THIENO 2 SUBSTITUTED THIENOPYRIMIDINES STRUCTURAL MODIFICATIONS ANTIBACTERIAL AGENTS Thieno[2,3-d] pyrimidine as a promising scaffold in medicinal chemistry: Recent advances Article 10.1016/j.bmc.2019.02.044 1 BIOORGANIC & MEDICINAL CHEMISTRY, v.27, no.7, pp.1159 - 1194 BIOORGANIC & MEDICINAL CHEMISTRY 27 7 1159 1194 scie scopus 000461168400002 2-s2.0-85062071370 Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Review RECEPTOR TYROSINE KINASE INITIATION-FACTOR 4E BIOLOGICAL EVALUATION DERIVATIVES BEARING ANTICANCER ACTIVITY 3-D PYRIMIDINE THIENO 2 SUBSTITUTED THIENOPYRIMIDINES STRUCTURAL MODIFICATIONS ANTIBACTERIAL AGENTS Thienopyrimidine Anti-inflammatory Anticancer Antimicrobial Antiviral CNS protective agents