Lih, Eugene Park, Wooram Park, Ki Wan Chun, So Young Kim, Hyuncheol Joung, Yoon Ki Kwon, Tae Gyun Hubbell, Jeffrey A. Han, Dong Keun 2024-01-19T20:31:41Z 2024-01-19T20:31:41Z 2021-09-02 2019-03-27 2374-7943 https://pubs.kist.re.kr/handle/201004/120193 Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide-co-glycolide) (PLGA), magnesium hydroxide (Mg(OH)(2)), and decellularized renal extracellular matrix (ECM). The Mg(OH)(2) inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH)(2) scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH)(2) scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment. English AMER CHEMICAL SOC PUBLIC-HEALTH PROBLEM KIDNEY-DISEASE GROWTH-FACTOR IN-VIVO PLGA DEGRADATION MICROSPHERES FABRICATION COMPLEMENT PROTEINS A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration Article 10.1021/acscentsci.8b00812 1 ACS CENTRAL SCIENCE, v.5, no.3, pp.458 - 467 ACS CENTRAL SCIENCE 5 3 458 467 scie scopus 000462498900012 2-s2.0-85060724097 Chemistry, Multidisciplinary Chemistry Article PUBLIC-HEALTH PROBLEM KIDNEY-DISEASE GROWTH-FACTOR IN-VIVO PLGA DEGRADATION MICROSPHERES FABRICATION COMPLEMENT PROTEINS