Kim, E. Kim, H.J. Oh, H.-N. Kwak, A.-W. Kim, S.-N. Kang, B.Y. Cho, S.-S. Shim, J.-H. Yoon, G. 2024-01-19T20:33:53Z 2024-01-19T20:33:53Z 2021-08-31 2019-03 1226-3907 https://pubs.kist.re.kr/handle/201004/120318 Bioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with IC50 values of 9.15 and 13.95 ？M, respectively. ？ 2019, Korean Society of Pharmacognosy. All rights reserved. English Korean Society of Pharmacognosy 2e,4e,8z,10e n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide 2e,4e,8z,10z n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide asarinin Asarum sieboldii extract fluorouracil methylkakuol plant extract sesamin unclassified drug xanthoxylol antineoplastic activity Article Asarum sieboldii breast cancer carbon nuclear magnetic resonance cell viability chemical structure controlled study cytotoxicity drug synthesis human human cell IC50 infrared spectroscopy MCF-7 cell line MDA-MB-231 cell line medicinal plant MTT assay proton nuclear magnetic resonance Cytotoxic constituents from the roots of asarum sieboldii in human breast cancer cells Article 10.20307/NPS.2019.25.1.72 1 Natural Product Sciences, v.25, no.1, pp.72 - 75 Natural Product Sciences 25 1 72 75 scopus kci 2-s2.0-85071928113 Article 2e,4e,8z,10e n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide 2e,4e,8z,10z n (2 methylpropyl) dodeca 2,4,8,10 tetraenamide asarinin Asarum sieboldii extract fluorouracil methylkakuol plant extract sesamin unclassified drug xanthoxylol antineoplastic activity Article Asarum sieboldii breast cancer carbon nuclear magnetic resonance cell viability chemical structure controlled study cytotoxicity drug synthesis human human cell IC50 infrared spectroscopy MCF-7 cell line MDA-MB-231 cell line medicinal plant MTT assay proton nuclear magnetic resonance Asarum sieboldii Breast cancer Cytotoxicity Xanthoxylol