Lee, Jooyoung Song, Boa Subbiah, Ramesh Chung, Justin J. Choi, U. Hyeok Park, Kwideok Kim, Sang-Heon Oh, Seung Ja 2024-01-19T20:34:11Z 2024-01-19T20:34:11Z 2021-09-02 2019-02-21 2045-2322 https://pubs.kist.re.kr/handle/201004/120333 Hydrogels have been developed and applied to various biomedical applications due to their biocompatibility. However, understanding of modulation between cells to hydrogel interface is still unclear, and parameters to explain the interaction are not sophisticated enough. In this report, we studied the effect of polymer chain flexibility on cell adhesion to various hydrogel constructs of collagen and fibrin gels. Specifically, novel method of semi-flexible model-based analysis confirmed that chain flexibility mediated microstructure of the hydrogels is a critical factor for cell adhesion on their surfaces. The proposed analysis showed possibility of more accurate prediction of biocompatibility of hydrogels, and it should be considered as one of the important criteria for polymer design and selections for enhancing both biocompatibility and biofunctionality. English NATURE PUBLISHING GROUP COLLAGEN STIFFNESS NETWORKS MODULUS Effect of chain flexibility on cell adhesion: Semi-flexible model-based analysis of cell adhesion to hydrogels Article 10.1038/s41598-019-38951-7 1 SCIENTIFIC REPORTS, v.9 SCIENTIFIC REPORTS 9 scie scopus 000459281500032 2-s2.0-85061916469 Multidisciplinary Sciences Science & Technology - Other Topics Article COLLAGEN STIFFNESS NETWORKS MODULUS