Hyung, Sujin Im, Sun-Kyoung Lee, Bo Yoon Shin, Jihye Park, Jong-Chul Lee, Cheolju Suh, Jun-Kyo Francis Hur, Eun-Mi 2024-01-19T21:01:20Z 2024-01-19T21:01:20Z 2021-09-02 2019-02 0894-1491 https://pubs.kist.re.kr/handle/201004/120421 Schwann cells (SCs), the primary glia in the peripheral nervous system (PNS), display remarkable plasticity in that fully mature SCs undergo dedifferentiation and convert to repair SCs upon nerve injury. Dedifferentiated SCs provide essential support for PNS regeneration by producing signals that enhance the survival and axon regrowth of damaged neurons, but the identities of neurotrophic factors remain incompletely understood. Here we show that SCs express and secrete progranulin (PGRN), depending on the differentiation status of SCs. PGRN expression and secretion markedly increased as primary SCs underwent dedifferentiation, while PGRN secretion was prevented by administration of cAMP, which induced SC differentiation. We also found that sciatic nerve injury, a physiological trigger of SC dedifferentiation, induced PGRN expression in SCs in vivo. These results suggest that dedifferentiated SCs express and secrete PGRN that functions as a paracrine factor to support the survival and axon growth of neighboring neurons after injury. English WILEY FRONTOTEMPORAL LOBAR DEGENERATION GRANULIN-EPITHELIN PRECURSOR POLYMORPHISM RS5848 NEUROTROPHIC FACTOR PERIPHERAL-NERVE EXPRESSION MUTATIONS BRAIN MYELINATION MECHANISMS Dedifferentiated Schwann cells secrete progranulin that enhances the survival and axon growth of motor neurons Article 10.1002/glia.23547 1 GLIA, v.67, no.2, pp.360 - 375 GLIA 67 2 360 375 scie scopus 000457061500011 2-s2.0-85056622951 Neurosciences Neurosciences & Neurology Article FRONTOTEMPORAL LOBAR DEGENERATION GRANULIN-EPITHELIN PRECURSOR POLYMORPHISM RS5848 NEUROTROPHIC FACTOR PERIPHERAL-NERVE EXPRESSION MUTATIONS BRAIN MYELINATION MECHANISMS dedifferentiation motor neurons progranulin Schwann cells secretion