Thi-Thuy Duong Pham Seo, Young Hun Lee, Dabin Noh, Juran Chae, Jeongwan Kang, Eunah Park, JaeHong Shin, Tae Joo Kim, Sehoon Park, Juhyun 2024-01-19T21:02:10Z 2024-01-19T21:02:10Z 2021-09-02 2019-01-14 0032-3861 https://pubs.kist.re.kr/handle/201004/120467 We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. Hybrid nanoparticles of a conjugated polymer (PCPDTBT), a phospholipid (D8PE) with a primary amine polar head, and iron oxide (Fe3O4) nanoparticles were prepared by a phase-separated film shattering process by varying the iron oxide concentration while maintaining a fixed mixing ratio of PCPDTBT and D8PE. Notably, the hybrid nanoparticles assembled at a molar mixing ratio of 1:1:0.8 (PCPDTBT/D8PE/Fe3O4) exhibited the shortest transversal relaxation time, T-2, and a photoacoustic signal 22 times higher than that obtained at the 1:1:0 mixing ratio. Structural analysis by X-ray diffraction together with the measurements of energy transfer by transient absorption spectroscopy confirmed that the structural ordering of these hybrid nanoparticles was responsible for their enhanced photoacoustic and magnetic properties. English ELSEVIER SCI LTD INFRARED PHOTOTHERMAL THERAPY BRANCHED SIDE-CHAINS POLYPYRROLE NANOPARTICLES CANCER-THERAPY IRON-OXIDE FILMS NANOCOMPOSITES MORPHOLOGY IMPACT CRYSTALLIZATION Ordered assemblies of Fe3O4 and a donor-acceptor-type pi-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects Article 10.1016/j.polymer.2018.12.020 1 POLYMER, v.161, pp.205 - 213 POLYMER 161 205 213 scie scopus 000454931700023 2-s2.0-85059560855 Polymer Science Polymer Science Article INFRARED PHOTOTHERMAL THERAPY BRANCHED SIDE-CHAINS POLYPYRROLE NANOPARTICLES CANCER-THERAPY IRON-OXIDE FILMS NANOCOMPOSITES MORPHOLOGY IMPACT CRYSTALLIZATION Conjugated polymers Iron oxides Hybrid nanoparticles Photoacoustic imaging Magnetic resonance imaging