Mun, Dong-Gi Bhin, Jinhyuk Kim, Sangok Kim, Hyunwoo Jung, Jae Hun Jung, Yeonjoo Jang, Ye Eun Park, Jong Moon Kim, Hokeun Jung, Yeonhwa Lee, Hangyeore Bae, Jingi Back, Seunghoon Kim, Su-Jin Kim, Jieun Park, Heejin Li, Honglan Hwang, Kyu-Baek Park, Young Soo Yook, Jeong Hwan Kim, Byung Sik Kwon, Sun Young Ryu, Seung Wan Park, Do Youn Jeon, Tae Yong Kim, Dae Hwan Lee, Jae-Hyuck Han, Sang-Uk Song, Kyu Sang Park, Dongmin Park, Jun Won Rodriguez, Henry Kim, Jaesang Lee, Hookeun Kim, Kwang Pyo Yang, Eun Gyeong Kim, Hark Kyun Paek, Eunok Lee, Sanghyuk Lee, Sang-Won Hwang, Daehee 2024-01-19T21:02:11Z 2024-01-19T21:02:11Z 2021-09-02 2019-01-14 1535-6108 https://pubs.kist.re.kr/handle/201004/120468 We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune-and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs. English CELL PRESS MICROSATELLITE INSTABILITY MOLECULAR SUBTYPES SIGNALING PATHWAY DATABASE SEARCH ACCURATE MASS IDENTIFICATION MUTATIONS DISCOVERY GENE KINASE Proteogenomic Characterization of Human Early-Onset Gastric Cancer Article 10.1016/j.ccell.2018.12.003 1 CANCER CELL, v.35, no.1, pp.111 - + CANCER CELL 35 1 111 + scie scopus 000455719400012 2-s2.0-85059409840 Oncology Cell Biology Oncology Cell Biology Article MICROSATELLITE INSTABILITY MOLECULAR SUBTYPES SIGNALING PATHWAY DATABASE SEARCH ACCURATE MASS IDENTIFICATION MUTATIONS DISCOVERY GENE KINASE cancer subtypes correlation between mRNA and protein abundance changes correlation between mutation and phosphorylation diffuse gastric cancer proteogenomics somatic nonsynonymous mutations