Kwon, Oh Seok Song, Hyun Seok Park, Tai Hyun Jang, Jyongsik 2024-01-19T21:02:20Z 2024-01-19T21:02:20Z 2021-09-02 2019-01-09 0009-2665 https://pubs.kist.re.kr/handle/201004/120476 One of the recently emerging topics in biotechnology is natural receptors including G protein-coupled receptors, ligand-gated ion channels, enzyme-linked receptors, and intracellular receptors, due to their molecular specificity. These receptors, other than intracellular receptors, which are membrane proteins expressed on the cell membrane, can detect extracellular stimuli. Many researchers have utilized cells with natural receptors embedded in the cellular membrane for human sense-mimicking platforms based on electrochemical impedance spectroscopy, quartz crystal micro balances, surface plasmon resonance, and surface acoustic waves. In addition, integration of conducting nanomaterials and natural receptors allows highly sensitive and selective responses toward target molecules, enabling, for example, nanobioelectronic noses for odorants, nanobioelectronic tongues for tastants, and G-protein-coupled receptor sensors for hormones, dopamine, cadaverine, geosmin, trimethylamine, etc. Moreover, as a part of nanobioelectronic sensors, natural receptors can be produced in various forms, such as peptides, proteins, nanovesicles, and nanodiscs, and each sensor can provide an ultralow limit of detection. In this Review, we discuss biosensors with natural receptors and then especially focus on natural receptor-conjugated conducting nanomaterial sensors. To provide a fundamental understanding, the sections encompass (1) the fabrication of conducting nanomaterials, (2) the production of natural receptors, (3) the characteristics of natural receptors, (4) the technology for immobilizing both components, and (5) their sensing applications. Finally, perspective is given on a new development in the use of natural receptors in a wide range of industries, such as food, cosmetics, and healthcare. In addition, artificial olfactory codes will be characterized by signal processing in the near future, leading to human olfactory standardization. English AMER CHEMICAL SOC PROTEIN-COUPLED RECEPTORS FIELD-EFFECT-TRANSISTOR HUMAN OLFACTORY RECEPTOR ODORANT-BINDING-PROTEIN WALLED CARBON NANOTUBES CHEMICAL-VAPOR-DEPOSITION LARGE-SCALE PRODUCTION HUMAN TASTE RECEPTOR CELL-BASED BIOSENSOR POTENTIOMETRIC ELECTRONIC TONGUE Conducting Nanomaterial Sensor Using Natural Receptors Article 10.1021/acs.chemrev.8b00159 1 CHEMICAL REVIEWS, v.119, no.1, pp.36 - 93 CHEMICAL REVIEWS 119 1 36 93 scie scopus 000455690300003 2-s2.0-85056211172 Chemistry, Multidisciplinary Chemistry Review PROTEIN-COUPLED RECEPTORS FIELD-EFFECT-TRANSISTOR HUMAN OLFACTORY RECEPTOR ODORANT-BINDING-PROTEIN WALLED CARBON NANOTUBES CHEMICAL-VAPOR-DEPOSITION LARGE-SCALE PRODUCTION HUMAN TASTE RECEPTOR CELL-BASED BIOSENSOR POTENTIOMETRIC ELECTRONIC TONGUE Conducting Nanomaterial Sensor Natural Receptor