Han, Sungmin Kim, Dong Hwee Sung, Joohwan Yang, Hwasun Park, Jong Woong Youn, Inchan 2024-01-19T21:02:22Z 2024-01-19T21:02:22Z 2021-09-02 2019-01-08 0006-291X https://pubs.kist.re.kr/handle/201004/120478 Electrical stimulation (ES) can be useful for promoting the regeneration of injured axons, but the mechanism underlying its positive effects is largely unknown. The current study aimed to investigate whether ES could enhance the regeneration of injured neurites in dorsal root ganglion explants and regulate the MMP-2 expression level, which is correlated with regeneration. Significantly increased neurite regeneration and MMP-2 expression was observed in the ES group compared with the sham group. However, an MMP inhibitor significantly decreased this ES-induced neurite regeneration. Our data suggest that the positive effect of ES on neurite regeneration could likely be mediated by an increase in MMP-2 expression, thereby promoting the regeneration of injured neurites. (C) 2018 Elsevier Inc. All rights reserved. English ACADEMIC PRESS INC ELSEVIER SCIENCE PERIPHERAL-NERVE INJURY MATRIX METALLOPROTEINASE-2 FUNCTIONAL RECOVERY PROMOTES GROWTH PATHOLOGY OUTGROWTH Electrical stimulation accelerates neurite regeneration in axotomized dorsal root ganglion neurons by increasing MMP-2 expression Article 10.1016/j.bbrc.2018.11.159 1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.508, no.2, pp.348 - 353 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 508 2 348 353 scie scopus 000456635900002 2-s2.0-85057274062 Biochemistry & Molecular Biology Biophysics Biochemistry & Molecular Biology Biophysics Article PERIPHERAL-NERVE INJURY MATRIX METALLOPROTEINASE-2 FUNCTIONAL RECOVERY PROMOTES GROWTH PATHOLOGY OUTGROWTH Electrical stimulation Matrix metalloproteinase Neurite regeneration Dorsal root ganglion